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KMID : 0363620100310030047
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Journal of Korean Oriental Medicine
2010 Volume.31 No. 3 p.47 ~ p.54
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Anti-inflammatory Effects of Sam-chul-kun-bi-tang
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Lee Jin-Ah
Ha Hye-Kyung
Jung Da-Young
Lee Ho-Young
Lee Nam-Hun
Lee Jun-Kyoung
Huang Dae-Sun
Shin Hyeun-Kyoo
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Abstract
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Objective: To derive information on the efficacy of Sam-chul-kun-bi-tang (SKT), by evaluating its anti-inflammatory effect. SKT is a widely-used herbal formula in traditional Korean medicine. In man y studies, plant-derived anti-inflammatory efficacies have been investigated for their potential inhibitory effects on lipopolysaccharide (LPS)-stimulated macrophages. This study was performed to examine the anti-inflammatory effects of SKT extract on LPS-stimulated RAW 264.7 cells.
Methods: The production of nitric oxide (NO), prostaglandin , tumor necrosis factor (TNF)- and interleukin (IL)-6 were examined in a macrophage cell line, RAW 264.7 cells, in the presence of SKT. RAW 264.7 cells were incubated with LPS 1 and SKT for 18 hrs. The anti-inflammatory activity of SKT was investigated by carrageenan-induced paw edema in rats. The paw volume was measured at 2 and 4 hrs following carrageenan-induced paw edema in rats.
Results: SKT showed inhibitory effect on , TNF- and IL-6 in LPS-stimulated RAW 264.7 cells. But SKT was not inhibitory effect on NO by LPS-stimulated RAW 264.7 cells. Administration of SKT (1 g/kg) also showed a reduction in carrageenan-induced paw edema on rats.
Conclusion: These results suggest that SKT has anti-inflammatory activities in both in vitro and in vivo models.
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KEYWORD
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Anti-inflammation, Sam-chul-kun-bi-tang, herbal formula, lipopolysaccharide (LPS)
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